There is a immense debate over the hazards and effectiveness of anti-aging treatments. A major question included in this dispute is whether the human aging process is an appropriate target for biomedical intervention or not.
A strong argument made in this article is that our society is not “designed to optimize the role of the elderly”. If this were changed and quality of life for the elderly were improved, would less people opt to receive anti-aging medication?
In our society today, the side effects and natural changes bodies undergo during the aging process have been given a negative connotation. They are and have been the source of much worry and resentment because they are considered losses by the people who are undergoing these changes. Some people argue that doctors are supposed to protect people from harms including aging and its effects. But critics of anti-aging medicine say that the negativity associated with the changes the body undergoes is influenced too much by the opinions of younger people who have not experienced them and for that matter, never want to. They also argue that by using anti-aging techniques, doctors are keeping people from experiencing the benefits of aging.
The article states that, “Public attitudes towards the enhancement technologies already available suggest that the demand for truly effective anti-aging interventions will be so substantial that legal prohibition would simply produce robust domestic or off-shore black markets.” This implies that there really is no point in trying to keep people from seeking these treatments because some way or another, they are going to find a way to get them.
So, who is right when it comes to this argument? Personally, I believe that if the anti-aging treatments are safe and effective, people should have the right to decide whether or not to take advantage of them. I understand both sides of the argument and recognize that each side presents valid points. I feel that people should have the freedom to control their own bodies. We are not talking about children here. We are talking about adults who have been making their own decisions regarding themselves and their bodies for many years. Especially when the adults are informed and knowledgeable about the procedure, others should not have the right to stop them from receiving these treatments. I believe that anti-aging treatments have a promising future and I think that if they are out there, we should take advantage of them. If we have the tools to improve the quality of peoples’ lives as they age, shouldn’t we use them?
http://www.liebertonline.com/doi/abs/10.1089/109454502317629318
Monday, November 23, 2009
Sunday, November 22, 2009
Anti-aging begins with vitamin supplements just don't get ripped off!
Advertisements are everywhere for the latest medical breakthrough: a pill, supplement, injection and/or treatment that will keep you looking and feeling young! Our world sometimes is shallow; companies will chose the better-looking person for the job even though both applicants have the same qualifications. Good looks, staying young, active and free of medical problems are essential in peoples developing careers and success rates. But have companies and avid businessmen taken this too far? Have they found a gateway to make quick money? It only makes since that people will go to all measures to buy pills that just might work, not taking into account that the ingredients might be the same as a multi-vitamin a hundred dollars cheaper in the grocery store or potentially harmful to their body. Many vitamin companies depend on the average consumer to not be well informed and they'll take billions of dollars from them each year. But let us first start to slow the aging process down with simple supplements you can take within your home, that DO NOT rip you off.
We know that scientists are discovering certain remedies to the aging process. We also know that there are some things we can do to slow down aging, but there still is not a cure to stay young forever. This article discusses the free radical theory and how aging results from oxidation due to free radical damage to genes, cells, membranes, blood vessels and organs. The article also suggests what can cure this degenerative disease; specifically with supplements that can be taken and which are knock-offs and which ones actually work. Antioxidants are good for us so we want to eat lots of colorful fruits and vegetables because they contain phytochemicals like carotenoids and flavonoids, which neutralize the free radicals that cause the age-related degenerative diseases. Additionally supplements like Vitamin C and Vitamin E and quasi-vitamins like CoQ10 and Alpha Lipoic Acid are very important in slowing the free-radical aging process and combating degenerative diseases like cancer, heart disease, cardiovascular disease, Alzheimers, diabetes, hypertension, cataracts and macular degeneration. All which normally appear in the older generations. And all which may be prevented, starting with vitamin supplements.
Make sure to consult a physician before relying on a specific supplement. Be careful not to believe all vitamin companies' advertisements that are vague and may potentially rip you off. Recently a TV news program showed two vitamin supplements found in a hospital bed-pan that were not digested at all. At the time this specific brand was one of the leading drug store supplements sold on America! However, not all vitamins are bed-pan bullets, the right supplements are essential to stop free radicals and slow down the aging process.
http://www.benefits-of-antioxidants.com/anti-aging.html (link on website: http://www.benefits-of-antioxidants.com/Articles/15-choosing-vitamin-supplements.htm)
We know that scientists are discovering certain remedies to the aging process. We also know that there are some things we can do to slow down aging, but there still is not a cure to stay young forever. This article discusses the free radical theory and how aging results from oxidation due to free radical damage to genes, cells, membranes, blood vessels and organs. The article also suggests what can cure this degenerative disease; specifically with supplements that can be taken and which are knock-offs and which ones actually work. Antioxidants are good for us so we want to eat lots of colorful fruits and vegetables because they contain phytochemicals like carotenoids and flavonoids, which neutralize the free radicals that cause the age-related degenerative diseases. Additionally supplements like Vitamin C and Vitamin E and quasi-vitamins like CoQ10 and Alpha Lipoic Acid are very important in slowing the free-radical aging process and combating degenerative diseases like cancer, heart disease, cardiovascular disease, Alzheimers, diabetes, hypertension, cataracts and macular degeneration. All which normally appear in the older generations. And all which may be prevented, starting with vitamin supplements.
Make sure to consult a physician before relying on a specific supplement. Be careful not to believe all vitamin companies' advertisements that are vague and may potentially rip you off. Recently a TV news program showed two vitamin supplements found in a hospital bed-pan that were not digested at all. At the time this specific brand was one of the leading drug store supplements sold on America! However, not all vitamins are bed-pan bullets, the right supplements are essential to stop free radicals and slow down the aging process.
http://www.benefits-of-antioxidants.com/anti-aging.html (link on website: http://www.benefits-of-antioxidants.com/Articles/15-choosing-vitamin-supplements.htm)
Longevity, genes, and aging
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6J-3VTYCC6-1&_user=489286&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1104694202&_rerunOrigin=google&_acct=C000022678&_version=1&_urlVersion=0&_userid=489286&md5=baad328e9a9ffc0b54109ce1772d8b37
We all know we age and get older but do we really understand why this is happening? Genetics is one of the two major factors of aging (environment being the other) and has revealed to us through research the importance of metabolic capacity, resistance to stress, integrity of gene regulation, and genetic stability of longevity.
The key gene that creates a balance between these life processes is maintained by the RAS2 gene (which also channels cellular resources among them). This gene not only collaborates with mitochondria and PHB1 in metabolic adjustments for longevity but also regulates stress responses. So one would think that if this RAS2 gene is one of the biggest factors in aging, why not give people more RAS2, resulting in a longer life span? Just like anything else in the world, too much of a good thing results in a bad thing or as the saying goes, “everything in moderation”. Having too much RAS activity abrogates the life extension. There must be an optimal level of RAS2 activity for the maximal life span to occur. Obtaining the optimal level of RAS2 for each individual is determined by the genetic background, epigenetic and environmental demands to which the individual is subjected to.
The RAS2 gene also works alongside with PHB1 gene that is involved with metabolic capacity. Studies have suggested that mitochondria, PHB1, and RAS2 partake in metabolic adjustments that are essential for longevity. These genes work together to signal a decreasing requirement for mitochondrial activity.
The RAS2 gene has been proven to be a main factor in the regulation of stress responses. RAS2 gene is important for the switching between different cellular states, and growth vs. response to stress. Although most people view stress as bad, and in most cases stress is bad, certain kinds of stress actually induce pathways, improving their fitness. Just as said before, too much of anything is a bad thing but everything in moderation is always good.
Other factors in the body also influence aging, such as transcriptional silencing. During aging, transcriptional silencing of heterochromatic regions of the genome is lost suggesting that gene dysregulation accompanies the aging process. Research has found that the gene CDC7 plays a role in silencing but RAS2 modulates it. Aging possesses features of nonlinear processes which RAS2 also has a role in.
Research has shown that much of aging is contributed to the RAS2 gene and its factors. I believe that we have come a long way in technology and research to start figuring out the body’s processes and what genes affect what processes. I find it fascinating that one gene can affect so many different genes and other processes in the body. I believe that we should continue to research the affects of different genes and learn how to influence them into doing what we want them to do, like aging more slowly. Genes are very under developed and I believe with more research and experiments we will learn a lot more about genes and how they can help us in life.
We all know we age and get older but do we really understand why this is happening? Genetics is one of the two major factors of aging (environment being the other) and has revealed to us through research the importance of metabolic capacity, resistance to stress, integrity of gene regulation, and genetic stability of longevity.
The key gene that creates a balance between these life processes is maintained by the RAS2 gene (which also channels cellular resources among them). This gene not only collaborates with mitochondria and PHB1 in metabolic adjustments for longevity but also regulates stress responses. So one would think that if this RAS2 gene is one of the biggest factors in aging, why not give people more RAS2, resulting in a longer life span? Just like anything else in the world, too much of a good thing results in a bad thing or as the saying goes, “everything in moderation”. Having too much RAS activity abrogates the life extension. There must be an optimal level of RAS2 activity for the maximal life span to occur. Obtaining the optimal level of RAS2 for each individual is determined by the genetic background, epigenetic and environmental demands to which the individual is subjected to.
The RAS2 gene also works alongside with PHB1 gene that is involved with metabolic capacity. Studies have suggested that mitochondria, PHB1, and RAS2 partake in metabolic adjustments that are essential for longevity. These genes work together to signal a decreasing requirement for mitochondrial activity.
The RAS2 gene has been proven to be a main factor in the regulation of stress responses. RAS2 gene is important for the switching between different cellular states, and growth vs. response to stress. Although most people view stress as bad, and in most cases stress is bad, certain kinds of stress actually induce pathways, improving their fitness. Just as said before, too much of anything is a bad thing but everything in moderation is always good.
Other factors in the body also influence aging, such as transcriptional silencing. During aging, transcriptional silencing of heterochromatic regions of the genome is lost suggesting that gene dysregulation accompanies the aging process. Research has found that the gene CDC7 plays a role in silencing but RAS2 modulates it. Aging possesses features of nonlinear processes which RAS2 also has a role in.
Research has shown that much of aging is contributed to the RAS2 gene and its factors. I believe that we have come a long way in technology and research to start figuring out the body’s processes and what genes affect what processes. I find it fascinating that one gene can affect so many different genes and other processes in the body. I believe that we should continue to research the affects of different genes and learn how to influence them into doing what we want them to do, like aging more slowly. Genes are very under developed and I believe with more research and experiments we will learn a lot more about genes and how they can help us in life.
What Your DNA Can Do For You
Current research in anti-aging medicine is intensifying in the field of genetics. In the early sixties, researchers found that human cells are mortal. This doesn't seem like a ground breaking discovery, but, it most likely can lead to a greater understanding of why cells wither over time, and how we can change that. DNA is the most fragile and important foundation of life. At each of its ends are sequences of non-coding DNA (junk DNA) called telomeres that protect genes from deterioration. In 1990, it was officially proven that as telomeric DNA shortens, aging continues on its inevitable path. Telomerase is the enzyme responsible for the synthesis and sustenance of telomeres. Once the protective DNA is diminished to a certain extent, aging (scientifically known as cellular senescence) begins. From that information alone we know how and why humans grow old. With the technology and resources available today it is possible to determine how to manipulate this enzyme in such a way that immortality isn't out of the question.
The progress already made by geneticists is either scary or amazing, depending on your perspective. hTERT is a type of reverse transcriptase (enzyme that serves as the catalyst for synthesizing DNA) linked to the activity of telomerase. Two studies found that the induced expression of this enzyme indeed lenghtened telomeres swiftly, translating to a longer mitotic cycle. This means that the cells were able to divide for a greater amount of time. These studies confirmed that telomeres are essentially the biological clock for humans.
In the modern world of biogerontology, I consider these advancements to be some of the most valuable to date. Before we can step back and look at the big picture of immortalization, we must thoroughly recognize what is occurring at the cellular level. If scientists were to eventually find the means for immortality, it is not likely be supported by the government or general public. However, solid research such as this deserves credit because it is meaningful. Other examples of anti-aging therapies and drugs which have been hastily released are solely based on profit to be received from naive consumers. Scientists involved in this biomedical field should be receiving funding and encouragement because this research is valid, and can only further our discoveries of the unknown.
http://www.liebertonline.com/doi/pdfplus/10.1089/rej.1.1998.1.125
The progress already made by geneticists is either scary or amazing, depending on your perspective. hTERT is a type of reverse transcriptase (enzyme that serves as the catalyst for synthesizing DNA) linked to the activity of telomerase. Two studies found that the induced expression of this enzyme indeed lenghtened telomeres swiftly, translating to a longer mitotic cycle. This means that the cells were able to divide for a greater amount of time. These studies confirmed that telomeres are essentially the biological clock for humans.
In the modern world of biogerontology, I consider these advancements to be some of the most valuable to date. Before we can step back and look at the big picture of immortalization, we must thoroughly recognize what is occurring at the cellular level. If scientists were to eventually find the means for immortality, it is not likely be supported by the government or general public. However, solid research such as this deserves credit because it is meaningful. Other examples of anti-aging therapies and drugs which have been hastily released are solely based on profit to be received from naive consumers. Scientists involved in this biomedical field should be receiving funding and encouragement because this research is valid, and can only further our discoveries of the unknown.
http://www.liebertonline.com/doi/pdfplus/10.1089/rej.1.1998.1.125
Wednesday, November 18, 2009
Anti-Aging Therapies
Anti-aging medicine is not in full force yet in the medical fields because there is still much researchers need to understand and prove about anti-aging methods. While caloric restriction, stress reduction and life-style changes can elongate life expactany, researchers are finding medicinal practices and therapies to further enhance this effect. Many different hormone and gene manipulations have proven in theory and animal clinical testing to be efficient in slowing the aging process. But major side effects and unproven and unfinished clinical trials hinder anti-aging medicine to be a full-blown force in the world of medicine. The International Longevity Center addresses these specific therapies, their success’s and problems, in its 2001 workshop report, “Is There Anti-Aging Medicine?
Genetic manipulations seem to be one of the best interventions for slowing the anti-aging process. The ILC gives fifteen examples of genes that were modified in animal testing and helped to increase life expectancy. But researchers are still unclear as to how each gene and its surrounding proteins are exactly involved with longevity. These scientists have been successful in proving their theory of manipulating growth hormone and therefore insulin-like growth factors in mammals but research is not sufficient enough. The ILC uses words like “appear, suggest, can”, all words of possibility but no definite answers. It will take much more research and assurance for to prove these anti-aging therapies will be successful practices.
Another similar practice that the ILC addresses is the very controversial hormone replacement therapy. Like genes that affect aging, circulating hormones like testosterone, estrogen, and dehydroepiandrosterone (DHEA) all decrease with age, speeding the process. Supplementing these hormones to slow aging seems great in theory, but yet again more research is needed to find the proper application of these hormones and to prove that the risks outweigh the benefits. For example, success had been made in beginning clinical trials such as improving the life expectancy of mice by five percent after supplementing them with the hormone melatonin. But, serious side effects (such as the sporadic tumors that started to show in the clinical mice) and the question as to how effective these hormones really are create obstacles to their legitimacy.
One of the hormone used for this practice that is most argued over is estrogen. Estrogen replacement therapy has had success in improving length and quality in women. The supplementation of estrogen can do wonders to a woman’s body including preventing osteoporosis, dementia, “inhibition of atherosclerotic plaque formation in arterial walls, increase in cardiac output, an increase in arterial flow velocity, a decrease in vascular resistance, and a decrease in systolic and diastolic blood pressure.” But there have been multiple concerns about the serious risks of estrogen replacement therapy like the development of ovarian cancer after a long period of treatment. But failure to prove that ERT can prevent cardio-vascular disease in patients who previously had it made the American Heart Association drop its support of ERT, starting a long battle of legitimacy for the therapy. What is most interesting about this fact and other risks of ERT (for example, the fact that it may stimulate growth in already existing tumors) is that it may be a case for specialized medicine. If ERT does not help with women who already have a breast tumor or who have had cardio vascular diseases, doctors can stratify patients into patient populations and treat them accordingly. While some trials have shown overall improvement in length and quality of life, question and concerns still linger and make people wary of ERT, just like the other unproven therapies for anti-aging.
http://biomed.gerontologyjournals.org/cgi/reprint/57/9/B333.pdf
Genetic manipulations seem to be one of the best interventions for slowing the anti-aging process. The ILC gives fifteen examples of genes that were modified in animal testing and helped to increase life expectancy. But researchers are still unclear as to how each gene and its surrounding proteins are exactly involved with longevity. These scientists have been successful in proving their theory of manipulating growth hormone and therefore insulin-like growth factors in mammals but research is not sufficient enough. The ILC uses words like “appear, suggest, can”, all words of possibility but no definite answers. It will take much more research and assurance for to prove these anti-aging therapies will be successful practices.
Another similar practice that the ILC addresses is the very controversial hormone replacement therapy. Like genes that affect aging, circulating hormones like testosterone, estrogen, and dehydroepiandrosterone (DHEA) all decrease with age, speeding the process. Supplementing these hormones to slow aging seems great in theory, but yet again more research is needed to find the proper application of these hormones and to prove that the risks outweigh the benefits. For example, success had been made in beginning clinical trials such as improving the life expectancy of mice by five percent after supplementing them with the hormone melatonin. But, serious side effects (such as the sporadic tumors that started to show in the clinical mice) and the question as to how effective these hormones really are create obstacles to their legitimacy.
One of the hormone used for this practice that is most argued over is estrogen. Estrogen replacement therapy has had success in improving length and quality in women. The supplementation of estrogen can do wonders to a woman’s body including preventing osteoporosis, dementia, “inhibition of atherosclerotic plaque formation in arterial walls, increase in cardiac output, an increase in arterial flow velocity, a decrease in vascular resistance, and a decrease in systolic and diastolic blood pressure.” But there have been multiple concerns about the serious risks of estrogen replacement therapy like the development of ovarian cancer after a long period of treatment. But failure to prove that ERT can prevent cardio-vascular disease in patients who previously had it made the American Heart Association drop its support of ERT, starting a long battle of legitimacy for the therapy. What is most interesting about this fact and other risks of ERT (for example, the fact that it may stimulate growth in already existing tumors) is that it may be a case for specialized medicine. If ERT does not help with women who already have a breast tumor or who have had cardio vascular diseases, doctors can stratify patients into patient populations and treat them accordingly. While some trials have shown overall improvement in length and quality of life, question and concerns still linger and make people wary of ERT, just like the other unproven therapies for anti-aging.
http://biomed.gerontologyjournals.org/cgi/reprint/57/9/B333.pdf
Bioidentical Hormone Replacement Therapy for Anti-Aging
http://www.worldhealth.net/news/bioidentical_hormone_replacement_therapy/
Age has always been one of the few aspects of life that was impossible to control, until now. Hormone replacement therapy (HRT) is a new biotechnological advancement that replaces the physiological levels of hormones that decline as a result of a specific disease state. The American Academy of Anti-Aging Medicine,A4M, (an international medical society of 18,500 physicians and scientists from 87 different countries composed of physicians responsible for the daily medical care of millions worldwide) supports the use of hormone replacement therapy and feels that it “…constitutes a legitimate and important life-enhancing, life-extending medical application.”
The biggest issue with hormone replacement therapy is the safety or lack thereof. Research has found through the A4M’s group’s Women’s Health Initiative study of healthy menopausal women that bio-identical hormones is the key to safety in hormone replacement therapy. Bio-identical hormones have the same chemical structure as those hormones that are made in the human body. The term “bio-identical” means that the chemical structure of the replacement hormone is exactly the same as the chemical structure found in the hormone naturally found in the body. Bio-identical hormone replacement therapy (BHRT) is the “…method by which replaced hormones follow normal metabolic pathways so that the essential active metabolites are formed in response to the treatment.” In terms of the safety of hormone replacement therapy, the molecular differences between bio-identical and non-bioidentical may prove to be the defining aspect. Natural, rather than synthetic, forms of hormones are associated with greater bio-availability (meaning that they are taken up by the body more easily and are utilized more efficiently).
I feel that hormone replacement therapy, and better yet, bio-identical hormone replacement therapy, is a great way to introduce anti-aging medicine. Experienced anti-aging physicians have been prescribing BHRT for over 20 years and numerous benefits have come from it. I believe that BRHT is still widely underdeveloped and still has many more benefits that will be discovered.
Another interesting fact about BHRT is how individualized it is. Hormone levels are different in every patient so with hormone therapy comes the appropriate monitoring of bio-available hormone levels and laboratory analysis for each patient. In doing this, the goal of anti-aging endocrinology will be achieved (“Safe optimization of essential hormone levels in the deficient and symptomatic patient”) and also, the most effective hormonal balance at the lowest possible dosage will be reached. I also think that this runs parallel to personalized medicine. Since every patient has different hormonal levels and needs to be monitored for different dosages, the medicines become personalized for the patient. This is also a new biotechnological advancement like hormone replacement therapy. I believe that by combining the two technologies together, it will make a stronger, more applicable field of medicine for a whole new field of patients.
I strongly believe in BHRT and its benefits. I also believe that with the proper modifications and adjustments done by an experienced physician, the benefits will largely outweigh the risks.
Age has always been one of the few aspects of life that was impossible to control, until now. Hormone replacement therapy (HRT) is a new biotechnological advancement that replaces the physiological levels of hormones that decline as a result of a specific disease state. The American Academy of Anti-Aging Medicine,A4M, (an international medical society of 18,500 physicians and scientists from 87 different countries composed of physicians responsible for the daily medical care of millions worldwide) supports the use of hormone replacement therapy and feels that it “…constitutes a legitimate and important life-enhancing, life-extending medical application.”
The biggest issue with hormone replacement therapy is the safety or lack thereof. Research has found through the A4M’s group’s Women’s Health Initiative study of healthy menopausal women that bio-identical hormones is the key to safety in hormone replacement therapy. Bio-identical hormones have the same chemical structure as those hormones that are made in the human body. The term “bio-identical” means that the chemical structure of the replacement hormone is exactly the same as the chemical structure found in the hormone naturally found in the body. Bio-identical hormone replacement therapy (BHRT) is the “…method by which replaced hormones follow normal metabolic pathways so that the essential active metabolites are formed in response to the treatment.” In terms of the safety of hormone replacement therapy, the molecular differences between bio-identical and non-bioidentical may prove to be the defining aspect. Natural, rather than synthetic, forms of hormones are associated with greater bio-availability (meaning that they are taken up by the body more easily and are utilized more efficiently).
I feel that hormone replacement therapy, and better yet, bio-identical hormone replacement therapy, is a great way to introduce anti-aging medicine. Experienced anti-aging physicians have been prescribing BHRT for over 20 years and numerous benefits have come from it. I believe that BRHT is still widely underdeveloped and still has many more benefits that will be discovered.
Another interesting fact about BHRT is how individualized it is. Hormone levels are different in every patient so with hormone therapy comes the appropriate monitoring of bio-available hormone levels and laboratory analysis for each patient. In doing this, the goal of anti-aging endocrinology will be achieved (“Safe optimization of essential hormone levels in the deficient and symptomatic patient”) and also, the most effective hormonal balance at the lowest possible dosage will be reached. I also think that this runs parallel to personalized medicine. Since every patient has different hormonal levels and needs to be monitored for different dosages, the medicines become personalized for the patient. This is also a new biotechnological advancement like hormone replacement therapy. I believe that by combining the two technologies together, it will make a stronger, more applicable field of medicine for a whole new field of patients.
I strongly believe in BHRT and its benefits. I also believe that with the proper modifications and adjustments done by an experienced physician, the benefits will largely outweigh the risks.
Monday, November 16, 2009
Methuselah Was How Old?!
The Methuselah Foundation is a non profit organization founded by biogerontologist, Aubrey De Grey and David Gobel in 2000. Its purpose is to support research in anti-aging methods. De Grey is the chief scientist of the Methuselah Project/Prize launched in 2003. The prize of 4.5 million dollars is awarded to the team of researchers who can extend the lifespan of mice the most. The title of the project came from Methuselah, a religious figure in the bible who lived to be 969 years old. There are two prizes given; one for longevity and the other for rejuvenation. The one awarded for rejuvenation concentrates on therapy beginning at an older age, that is to reverse the process at its onset. Donations contribute to the prize money.
For the longevity prize, only one mouse is required and researchers are permitted to apply both genetic engineering and breeding. To compete for rejuvenation, however, 20 mice are control and another 20 undergo some sort of therapy. When the mouse reaches mid life, rejuvenation treatment can commence. The record for rejuvenation was set in 2005 at 3.7 years. This mouse underwent calorie restriction, which is a method biogerontologists consider to be somewhat effective.
Obviously the bigger picture involves incentive for funding towards anti-aging research in humans. The genome of a mouse is 85% similar to that of a human, which is encouraging if we already made progress in mice. However, some argue that drosophila (the fruit fly) would be more ideal. Three quarters of defective genes in humans have a similar version in drosophila. In addition, more experiments that are less costly can be performed with fruit flies. Even so, this project is getting us closer to answers in anti-aging medicine and is stimulating the much needed funding to continue delving into the mysteries of this field. Maybe through continued studies in animals we will find it safe to do the same with human test subjects. As long as such research is done with appropriate regulations, determined after much debate of course, there is no reason not to pursue more knowledge. Click below for a link to a presentation by Aubrey De Grey:
http://www.youtube.com/watch?v=8iYpxRXlboQ
Article: http://www.lumrix.net/health/Methuselah_Mouse_Prize.html
For the longevity prize, only one mouse is required and researchers are permitted to apply both genetic engineering and breeding. To compete for rejuvenation, however, 20 mice are control and another 20 undergo some sort of therapy. When the mouse reaches mid life, rejuvenation treatment can commence. The record for rejuvenation was set in 2005 at 3.7 years. This mouse underwent calorie restriction, which is a method biogerontologists consider to be somewhat effective.
Obviously the bigger picture involves incentive for funding towards anti-aging research in humans. The genome of a mouse is 85% similar to that of a human, which is encouraging if we already made progress in mice. However, some argue that drosophila (the fruit fly) would be more ideal. Three quarters of defective genes in humans have a similar version in drosophila. In addition, more experiments that are less costly can be performed with fruit flies. Even so, this project is getting us closer to answers in anti-aging medicine and is stimulating the much needed funding to continue delving into the mysteries of this field. Maybe through continued studies in animals we will find it safe to do the same with human test subjects. As long as such research is done with appropriate regulations, determined after much debate of course, there is no reason not to pursue more knowledge. Click below for a link to a presentation by Aubrey De Grey:
http://www.youtube.com/watch?v=8iYpxRXlboQ
Article: http://www.lumrix.net/health/Methuselah_Mouse_Prize.html
The Ethics of Anti-Aging Therapy
The idea of extending life and immortality is nothing new. Countless myths and stories dating back to ages ago involve maintaining youth and avoiding death. However, within the past century or so, scientists have been working to make anti-aging medicine a reality. Thanks to biotechnology, this concept is taken very seriously and may become the god of all medical fields. Try to imagine the way health care works now being reversed. Rather than being diagnosed then treated for a given disease, we'd prevent most illnesses by keeping our cells young. As interesting and exciting as this sounds, the direction biogerontology is heading towards attracts plenty of controversy. We exist in a society where aging is feared and considered troublesome, but after all it is natural. What are the consequences of progressing with the approach that old age is "treatable"?
An article from the Hastings Center Report addresses the morals and repercussions if such medicine were to succeed. The divide is between the supportive scientists who claim "age reversal" will be attainable within ten years and those who deem it completely unnecessary. Ever since this field truly surfaced at the start of the twenty first century with some substantial support, other biogerontologists regard the idea of anti-aging treatment as non legitimate. The difference lies between those who pursue the "cure" of aging and those who are in the field simply to gain an understanding of how it works. Scientists who do not believe that aging is a disease question why we would try to prevent a stage of life from occurring.
On the other hand, the National Institute on Aging began a "Strategic Plan" in 2001, creating a research goal to slow aging and decrease its debilitating effects. Now a grey area is formed. Is it incorrect to refer to anti-aging drugs/therapies as medicinal? If old age isn't pathological in the first place then shouldn't it be considered "enhancement"? Completely disregarding this idea isn't smart in my opinion, keeping in mind that it is a fairly new field that can potentially help us discover ways to eradicate diseases like cancer. Improving the quality of life is a justified reason to move forward with research. However, biotechnology is only going to open more realms of morally questionable advances. As the authors stated in the article, the public will react to advertising based on their education and experience. It's risky to promote anti-aging substances to the general public while the field itself is in a fragile and elementary stage. How far can we take the ultimate goal of longevity before the meaning of life itself is totally changed?
Article: http://www.jstor.org/stable/3528377?seq=1
An article from the Hastings Center Report addresses the morals and repercussions if such medicine were to succeed. The divide is between the supportive scientists who claim "age reversal" will be attainable within ten years and those who deem it completely unnecessary. Ever since this field truly surfaced at the start of the twenty first century with some substantial support, other biogerontologists regard the idea of anti-aging treatment as non legitimate. The difference lies between those who pursue the "cure" of aging and those who are in the field simply to gain an understanding of how it works. Scientists who do not believe that aging is a disease question why we would try to prevent a stage of life from occurring.
On the other hand, the National Institute on Aging began a "Strategic Plan" in 2001, creating a research goal to slow aging and decrease its debilitating effects. Now a grey area is formed. Is it incorrect to refer to anti-aging drugs/therapies as medicinal? If old age isn't pathological in the first place then shouldn't it be considered "enhancement"? Completely disregarding this idea isn't smart in my opinion, keeping in mind that it is a fairly new field that can potentially help us discover ways to eradicate diseases like cancer. Improving the quality of life is a justified reason to move forward with research. However, biotechnology is only going to open more realms of morally questionable advances. As the authors stated in the article, the public will react to advertising based on their education and experience. It's risky to promote anti-aging substances to the general public while the field itself is in a fragile and elementary stage. How far can we take the ultimate goal of longevity before the meaning of life itself is totally changed?
Article: http://www.jstor.org/stable/3528377?seq=1
Sunday, November 15, 2009
Can the human growth hormone reduce the aging process?
For centuries people have been searching for ways to increase longevity, but is the human growth hormone (hGH) really the answer?
We know that with exercise, the right diet, and specific supplements people can increase their internal health, possibly lengthening their lives by preventing disease, but is there an easier way? Some physicians say hGH injections in aging adults will help the aging process; however, a contradicting study says otherwise.
This article was published in 2006, although it may be ancient history to the growing research and development on anti-aging medicine today, we still need to take into account what it has to say about hGH injections and are they a scam? HGH is indeed an anti-aging medicine; however, there are several risks involved in taking this medication. One study showed that hGH did not increase strength, improve exercise capabilities, intellectual skills, memory or prevent depression (signs of aging not cured by anti-aging medicine). This article also mentions a study including adults with real growth hormone deficiency that only experienced results during the 24 months of treatment and then the results diminished. Furthermore, older individuals had significant side effects. This is necessary to take into account because this generation would be the buyers of anti-aging products. Treated participants developed carpal tunnel syndrome, swelling, joint pain, and developed pre-diabetes or diabetes. There is also a concern about the possibility of an increased cancer risk with long-term hGH treatment. The hormone induced by hGH, insulin growth factor-1 (IGF-1), promotes the growth of cells and prevents them from dying. And that’s exactly what cancer cells do — they grow wildly and don’t die!
This article totally contradicts what other industries are trying to promote. And yet the United States is putting their money where they deem valuable, nowadays it is to look like the latest movie star on the cover of People Magazine. Billions of dollars are going into research and development to slow down the aging process. Even if there are hundreds of studies stating that hGH injections are helpful to aging, the side effects to high levels of hGH do not seem worth it and overall are barely helpful. Conversely, it is your choice. What do you value? A few months of incresed muscle tissue or a natural, healthy life.
http://www.msnbc.msn.com/id/10766061/
We know that with exercise, the right diet, and specific supplements people can increase their internal health, possibly lengthening their lives by preventing disease, but is there an easier way? Some physicians say hGH injections in aging adults will help the aging process; however, a contradicting study says otherwise.
This article was published in 2006, although it may be ancient history to the growing research and development on anti-aging medicine today, we still need to take into account what it has to say about hGH injections and are they a scam? HGH is indeed an anti-aging medicine; however, there are several risks involved in taking this medication. One study showed that hGH did not increase strength, improve exercise capabilities, intellectual skills, memory or prevent depression (signs of aging not cured by anti-aging medicine). This article also mentions a study including adults with real growth hormone deficiency that only experienced results during the 24 months of treatment and then the results diminished. Furthermore, older individuals had significant side effects. This is necessary to take into account because this generation would be the buyers of anti-aging products. Treated participants developed carpal tunnel syndrome, swelling, joint pain, and developed pre-diabetes or diabetes. There is also a concern about the possibility of an increased cancer risk with long-term hGH treatment. The hormone induced by hGH, insulin growth factor-1 (IGF-1), promotes the growth of cells and prevents them from dying. And that’s exactly what cancer cells do — they grow wildly and don’t die!
This article totally contradicts what other industries are trying to promote. And yet the United States is putting their money where they deem valuable, nowadays it is to look like the latest movie star on the cover of People Magazine. Billions of dollars are going into research and development to slow down the aging process. Even if there are hundreds of studies stating that hGH injections are helpful to aging, the side effects to high levels of hGH do not seem worth it and overall are barely helpful. Conversely, it is your choice. What do you value? A few months of incresed muscle tissue or a natural, healthy life.
http://www.msnbc.msn.com/id/10766061/
Anti-Aging Medicine; What is it and how does it work? By: Maddi Tropp-Bluestone
In our society today, people are dying to be young and trying to live forever. We will do whatever it takes to increase our longevity. While there is no known treatment to make people live forever, physicians and researchers have made tremendous progress when it comes to anti-aging treatments. While most articles I have come across on anti-aging have expressed negative attitudes and opinions, this one did not. The outlook of this medicine seems promising. According to the U.S. Census Bureau, approximately 1.3 million people will celebrate their 100th birthdays by 2040. The article stressed the fact that treatments to retard aging are evolving quickly and instead of being “hit-or-miss” they are becoming much more consistent and individualized. Regimens are created according to the patient’s individual needs. Treatment to slow aging usually consists of a combination of nutrients, drugs, and hormones. Sometimes surgery is also incorporated into the regimen.
A huge success in anti-aging has been HGH, or human growth hormone. It has many benefits on the body like improving organ function and the effectiveness of the immune system. Generally, it improves peoples’ health overall. This however is not the only thing needed for this treatment to be successful. Lifestyle choices play a huge role in anti-aging. A healthy diet and exercise are crucial to assist in the success of this remedy. Anti-aging regimens can greatly improve the quality of life for elderly people and can positively affect age-related degenerative diseases like Alzheimer’s and Parkinson’s.
Although there are many critics of anti-aging treatments, it seems to have many benefits and looks like it will be a promising remedy in the future. Researchers are working hard to improve the current treatments and to discover other ways to slow the aging process and ultimately to keep people forever young.
http://www.liebertonline.com/doi/abs/10.1089/act.1995.1.328
A huge success in anti-aging has been HGH, or human growth hormone. It has many benefits on the body like improving organ function and the effectiveness of the immune system. Generally, it improves peoples’ health overall. This however is not the only thing needed for this treatment to be successful. Lifestyle choices play a huge role in anti-aging. A healthy diet and exercise are crucial to assist in the success of this remedy. Anti-aging regimens can greatly improve the quality of life for elderly people and can positively affect age-related degenerative diseases like Alzheimer’s and Parkinson’s.
Although there are many critics of anti-aging treatments, it seems to have many benefits and looks like it will be a promising remedy in the future. Researchers are working hard to improve the current treatments and to discover other ways to slow the aging process and ultimately to keep people forever young.
http://www.liebertonline.com/doi/abs/10.1089/act.1995.1.328
A Brief History of Anti-Aging/Age Management Medicine
http://images.antiagingconference.com/files/1103/aagateway/history.asp
Anti-aging conference presents a brief history of anti-aging medicine. Although anti-aging medicine is a relatively new field, research on anti-aging has been going on since the 1930s. The Josiah Macy Foundation was one of the main foundations that supported the research of anti-aging medicine when it was first being discovered. Since then, much more research has been done and also more breakthroughs have been found. Scientists and researchers have found that there are multiple components to anti-aging medicine. They consist of, “a combination of battery tests intended to measure biological age, suggested dietary modifications, exercise instruction, and the introduction of a suite of hormones and nutritional supplements. The underlying premise is that if physiological parameters that are believed to measure biological age can be modified so that they resemble levels present at younger ages, then it is believed that aging has been reversed and length and quality of life extended.”
There is no magical pill that a person can take to stop from aging but Americans are still investing billions of dollars each year, $44.6 billion alone last year, to try and find the magic bullet. I believe that anti-aging medicine has a promising future, especially since the public is so willing to invest in the research of anti-aging medicine. While some people are only hoping to use anti-aging medicine for physical beauty, I feel that this medicine also has remarkable benefits in improving the quality of life of people as they age. It is only a matter of time before researchers find the magic bullet.
Anti-aging conference presents a brief history of anti-aging medicine. Although anti-aging medicine is a relatively new field, research on anti-aging has been going on since the 1930s. The Josiah Macy Foundation was one of the main foundations that supported the research of anti-aging medicine when it was first being discovered. Since then, much more research has been done and also more breakthroughs have been found. Scientists and researchers have found that there are multiple components to anti-aging medicine. They consist of, “a combination of battery tests intended to measure biological age, suggested dietary modifications, exercise instruction, and the introduction of a suite of hormones and nutritional supplements. The underlying premise is that if physiological parameters that are believed to measure biological age can be modified so that they resemble levels present at younger ages, then it is believed that aging has been reversed and length and quality of life extended.”
There is no magical pill that a person can take to stop from aging but Americans are still investing billions of dollars each year, $44.6 billion alone last year, to try and find the magic bullet. I believe that anti-aging medicine has a promising future, especially since the public is so willing to invest in the research of anti-aging medicine. While some people are only hoping to use anti-aging medicine for physical beauty, I feel that this medicine also has remarkable benefits in improving the quality of life of people as they age. It is only a matter of time before researchers find the magic bullet.
A Struggle for Legitimacy
Anti-Aging Medicine and Research: A Realm of Conflict and Profound Societal Implications
http://biomed.gerontologyjournals.org/cgi/reprint/59/6/B523
In his 2004 article Anti-Aging Medicine and Research: A Realm of Conflict and Profound Societal Implications, published in the Journal of Gerontology, Robert H. Binstock explained the war on anti-aging medicine and its fight to gain legitimacy. One of the most interesting things about all the discredits toward anti-aging medicine is that they come from its core supporters and researchers.
The reasons behind these campaigns against anti-aging are merely efforts for the true facts and research to gain legitimacy, and to educate the public on fraudulent or misleading anti-aging claims. Multiple conferences to focus on these fraudulent marketing tactics and editorial denunciations have been made by major leaders in world of anti-aging medicine such as the U.S. Senate Special Committee on Aging and the editor-in-chief of Experimental Gerontology.
Anti-aging medicinal practices have not yet been perfected and gerontological researchers want to warn the public of possible serious adverse effects such as diabetes, glucose intolerance, cancer, dementia, coronary heart disease, stroke and pulmonary embolism. Researchers believe that keeping the public from engaging in these ineffective practices will prevent them from opting out of future practices that will actually be safe and effective.
The fight to gain this legitimacy is a smart one. Gerontological researchers know that they need the optimism to keep their current political and scientific legitimacy as well as maintain funding and support for a successful future. Binstock explains that gerontologists are merely trying to separate themselves from the mythical hunters of the “Fountain of Youth,” but rather be viewed as established biological and medical researchers.
http://biomed.gerontologyjournals.org/cgi/reprint/59/6/B523
In his 2004 article Anti-Aging Medicine and Research: A Realm of Conflict and Profound Societal Implications, published in the Journal of Gerontology, Robert H. Binstock explained the war on anti-aging medicine and its fight to gain legitimacy. One of the most interesting things about all the discredits toward anti-aging medicine is that they come from its core supporters and researchers.
The reasons behind these campaigns against anti-aging are merely efforts for the true facts and research to gain legitimacy, and to educate the public on fraudulent or misleading anti-aging claims. Multiple conferences to focus on these fraudulent marketing tactics and editorial denunciations have been made by major leaders in world of anti-aging medicine such as the U.S. Senate Special Committee on Aging and the editor-in-chief of Experimental Gerontology.
Anti-aging medicinal practices have not yet been perfected and gerontological researchers want to warn the public of possible serious adverse effects such as diabetes, glucose intolerance, cancer, dementia, coronary heart disease, stroke and pulmonary embolism. Researchers believe that keeping the public from engaging in these ineffective practices will prevent them from opting out of future practices that will actually be safe and effective.
The fight to gain this legitimacy is a smart one. Gerontological researchers know that they need the optimism to keep their current political and scientific legitimacy as well as maintain funding and support for a successful future. Binstock explains that gerontologists are merely trying to separate themselves from the mythical hunters of the “Fountain of Youth,” but rather be viewed as established biological and medical researchers.
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